Abstract: In order to assess health risk of Epinephelinae, Takifugu bimaculatus and Larimichthys crocea caused by polycyclic aromatic hydrocarbons (PAHs), three cultured fish and water were collected from main production area of Fujian Province coast in China, and the concentration of 16 types of PAHs were detected, respectively. The margin of exposure (MOE) and total carcinogenic risk index (RTC) of PAHs components were calculated. By comparing the health risk values, the main risk factors of PAHs could be concluded. Then the distribution and variation features of main risk factors were also discussed. The results showed that the average MOE of contaminants were between 2.53×10-6~6.45×10-5 which was less than the limit value, while the average RTC were between 1.08×10-5~1.44×10-5 which was less than the maximum acceptable risk level of 10-4. Therefore, the health risk of the three aquaculture fish caused by PAHs were acceptable. The main health risk factors of PAHs in the three aquaculture fishes were five ring BaP and DBahA. The primary components of PAHs in aquaculture water and fish were three ring PAHs. The pollution sources of different site water were similar, but fish were more complex. The PAHs concentration had no significant correlation between aquaculture water and fish.